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LL-37(17-32)b
General Information
DRACP ID DRACP00154
Peptide Name LL-37(17-32)b
Sequence FKRIVQRIKDFLRNLV
Sequence Length 16
UniProt ID Q1KLX1 P49913 Q1KLX2
PubChem CID Not available
Origin LL-37,a series of peptide fragments
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| KBv | Human oral carcinoma | Carcinoma | LC50=25±1 µM | MTT assay | 24 h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50=30 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HBMEC: LC50=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C95H161N29O21
Absent amino acids ACEGHMPSTWY
Common amino acids R
Mass 231324
Pl 12.24
Basic residues 5
Acidic residues 1
Hydrophobic residues 8
Net charge 4
Boman Index -4304
Hydrophobicity -7.5
Aliphatic Index 133.75
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16637646
Title Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.