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LL-37(17-29)
General Information
DRACP ID DRACP00155
Peptide Name LL-37(17-29)
Sequence FKRIVQRIKDFLR
Sequence Length 13
UniProt ID P49913
PubChem CID Not available
Origin LL-37,a series of peptide fragments
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| KBv | Human oral carcinoma | Carcinoma | LC50=60 µM | MTT assay | 24 h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50=57 µM | MTT assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=20.1 μg/ml | MTT assay | 24 h | 2 |
Hemolytic Activity Human erythrocytes: Not active up to 500 µg/ml
Normal (non-cancerous) Cytotoxicity HBMEC: LC50=41 µM; DLF lung fibroblasts: IC50=29.3 μg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C80H135N25O17
Absent amino acids ACEGHMNPSTWY
Common amino acids R
Mass 193333
Pl 12.24
Basic residues 5
Acidic residues 1
Hydrophobic residues 6
Net charge 4
Boman Index -4536
Hydrophobicity -43.85
Aliphatic Index 112.31
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16637646
Title Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
Year 2005
Literature 2
Pubmed ID 32567085
Title Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents
Doi 10.1002/psc.3254
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.