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LL-37(13-37)
General Information
DRACP ID DRACP00156
Peptide Name LL-37(13-37)
Sequence IGKEFKRIVQRIKDFLRNLVPRTES
Sequence Length 25
PubChem CID 102602726
Origin LL-37,a series of peptide fragments
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| KBv | Human oral carcinoma | Carcinoma | LC50=39 µM | MTT assay | 24 h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50=40 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HBMEC: LC50=38±3 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C137H232N42O36
Absent amino acids ACHMWY
Common amino acids R
Mass 347186
Pl 11.58
Basic residues 7
Acidic residues 3
Hydrophobic residues 9
Net charge 4
Boman Index -7724
Hydrophobicity -62.4
Aliphatic Index 101.2
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16637646
Title Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.