LL-37(13-37)

General Information


DRACP ID  DRACP00156

Peptide Name   LL-37(13-37)

Sequence  IGKEFKRIVQRIKDFLRNLVPRTES

Sequence Length  25

UniProt ID  Q1KLX1  P49913 

PubChem CID  102602726 

Origin  LL-37,a series of peptide fragments

Type  Synthetic peptide

Classification

  

Active ACP Induce apoptosis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
KBv Human oral carcinoma Carcinoma LC50=39 µM MTT assay 24 h 1
KB Human papillomavirus-related endocervical adenocarcinoma Carcinoma LC50=40 µM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HBMEC: LC50=38±3 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  2FCG 

Predicted Structure  DRACP00156

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C137H232N42O36

Absent amino acids  ACHMWY

Common amino acids  R

Mass  347186

Pl  11.58

Basic residues  7

Acidic residues  3

Hydrophobic residues  9

Net charge  4

Boman Index  -7724

Hydrophobicity  -62.4

Aliphatic Index  101.2

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 16637646

Title  Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region

Doi 10.1021/ja0584875

Year  2005

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




CancerPPD ID  1526

CancerPPD ID  1532

CancerPPD ID  1538

DBAASP ID  DBAASPS_3391

DRACP is developed by Dr.Zheng's team.