This work is licensed under a Creative Commons Attribution 4.0 International License.
D-K6L9
General Information
DRACP ID DRACP00157
Peptide Name D-K6L9
Sequence LKlLKKLlkKLLkLL
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Host Defense lytic Peptide
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| 22Rv1 | Prostate carcinoma | Carcinoma | LC50=6 μmol/L | ELISA assay | Not available | 1 |
| CL-1 | Canine leukemia | Leukemia | LC50=3 μmol/L | ELISA assay | Not available | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=3 μmol/L | ELISA assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target surface phosphatidylserine
Affinity Not available
Mechanism The exclusive selectivity of the peptide towards cancer derives from its specific binding to surface phosphatidylserine and the killing of the cancer cells via cytoplasmic membrane depolarization
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula C66H119N15O8
Absent amino acids ACDEFGHIMNPQRSTVWY
Common amino acids L
Mass 150068
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 7
Net charge 4
Boman Index 1224
Hydrophobicity 73.33
Aliphatic Index 182
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16707464
Title Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide
Doi 10.1158/0008-5472.CAN-05-4569
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.