Peptide Libraray

General Information

DRACP ID DRACP00159

Peptide Name 8

Sequence YX

Sequence Length 2

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HEp-2	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	14.2% inhibition at 10-6 M, 19.7% inhibition at 10-5 M, 24.9% inhibition at 10-4 M, 30.4% inhibition at 10-3 M	MTT assay	72 h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	10% inhibition at 10-5 M, 8.2% inhibition at 10-4 M, 36.1% inhibition at 10-3 M	MTT assay	72 h	1
HBL	Melanoma	Carcinoma	6.5% inhibition at 10-6 M, 14% inhibition at 10-5 M, 7.5% inhibition at 10-4 M, 14% inhibition at 10-3 M	MTT assay	72 h	1
HT-29	Colon adenocarcinoma	Carcinoma	9.8% inhibition at 10-6 M, 1.6% inhibition at 10-5 M, 5.4% inhibition at 10-4 M, 26.5% inhibition at 10-3 M	MTT assay	72 h	1
SW620	Colon adenocarcinoma	Carcinoma	12.9% inhibition at 10-6 M, 16.5% inhibition at 10-5 M, 28.1% inhibition at 10-4 M, 58.2% inhibition at 10-3 M	MTT assay	72 h	1
CaCo-2	Colon adenocarcinoma	Carcinoma	3.5% inhibition at 10-6 M, 22.7% inhibition at 10-5 M, 18.9% inhibition at 10-4 M, 26.4% inhibition at 10-3 M	MTT assay	72 h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	2.4% inhibition at 10-5 M, 7.5% inhibition at 10-3 M	MTT assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism lead to apoptosis

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification X=Cαα -dialkylated glycine (Aaa1 )

Chiral L

Physicochemical Information

Formula C9H9NO2

Absent amino acids ACDEFGHIKLMNPQRSTVW

Common amino acids YX

Mass 29119

Pl 6.09

Basic residues 0

Acidic residues 0

Hydrophobic residues 0

Net charge 0

Boman Index -14

Hydrophobicity -65

Aliphatic Index 0

Half Life
/

Extinction Coefficient cystines 1490

Absorbance 280nm 1490

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 16722632

Title Tumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity

Doi 10.1021/jm051026

Year +2006

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available