This work is licensed under a Creative Commons Attribution 4.0 International License.
10
General Information
DRACP ID DRACP00161
Peptide Name 10
Sequence YX
Sequence Length 2
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HEp-2 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 2.7% inhibition at 10-6 M, 2% inhibition at 10-5 M, 18.8% inhibition at 10-4 M, 26.7% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 7.2% inhibition at 10-6 M, 17.1% inhibition at 10-5 M, 11% inhibition at 10-4 M, 20.5% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| HBL | Melanoma | Carcinoma | 3% inhibition at 10-6 M, 4.7% inhibition at 10-5 M, 2.7% inhibition at 10-4 M, 7.3% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | 0.7% inhibition at 10-6 M, 8.3% inhibition at 10-5 M, 10.5% inhibition at 10-4 M, 21.8% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| SW620 | Colon adenocarcinoma | Carcinoma | 10.7% inhibition at 10-6 M, 10% inhibition at 10-5 M, 9.4% inhibition at 10-4 M, 18.7% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| CaCo-2 | Colon adenocarcinoma | Carcinoma | 22.2% inhibition at 10-6 M, 21.4% inhibition at 10-5 M, 17.5% inhibition at 10-4 M, 16% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | 1.6% inhibition at 10-6 M, 2.6% inhibition at 10-5 M, 7.7% inhibition at 10-4 M, 18.7% inhibition at 10-3 M | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism lead to apoptosis
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Cα -dialkylated glycine (Aaa2,R )
Chiral L
Physicochemical Information
Formula C9H9NO2
Absent amino acids ACDEFGHIKLMNPQRSTVW
Common amino acids YX
Mass 29119
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 0
Net charge 0
Boman Index -14
Hydrophobicity -65
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 1490
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16722632
Title Tumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity
Doi 10.1021/jm051026
Year +2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.