This work is licensed under a Creative Commons Attribution 4.0 International License.
18
General Information
DRACP ID DRACP00165
Peptide Name 18
Sequence YXGFM
Sequence Length 5
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HEp-2 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 13.7% inhibition at 10-6 M, 25.8% inhibition at 10-5 M, 34.7% inhibition at 10-4 M, 44.5% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 8.5% inhibition at 10-6 M, 9.5% inhibition at 10-5 M, 15.4% inhibition at 10-4 M, 24.1% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| HBL | Melanoma | Carcinoma | 2.4% inhibition at 10-6 M, 4.5% inhibition at 10-5 M, 11.4% inhibition at 10-4 M, 23.2% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | 16.2% inhibition at 10-6 M, 6.6% inhibition at 10-5 M, 5.1% inhibition at 10-4 M, 14.5% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| SW620 | Colon adenocarcinoma | Carcinoma | 26.4% inhibition at 10-6 M, 13.1% inhibition at 10-5 M, 14.6% inhibition at 10-4 M, 38.4% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| CaCo-2 | Colon adenocarcinoma | Carcinoma | 17.7% inhibition at 10-6 M, 10.9% inhibition at 10-5 M, 12.1% inhibition at 10-4 M, 8.1% inhibition at 10-3 M | MTT assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | 9.6% inhibition at 10-4 M, 29.9% inhibition at 10-4 M | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism lead to apoptosis
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Cα -dialkylated glycine (Aaa2)
Chiral L
Physicochemical Information
Formula C25H30N4O5S
Absent amino acids ACDEHIKLNPQRSTVW
Common amino acids FGMYX
Mass 68012
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 1
Net charge 0
Boman Index 613
Hydrophobicity 60
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 372.5
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16722632
Title Tumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity
Doi 10.1021/jm051026
Year +2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.