This work is licensed under a Creative Commons Attribution 4.0 International License.
Gaegurin-5
General Information
DRACP ID DRACP00167
Peptide Name Gaegurin-5
Sequence FLGALFKVASKVLPSVKCAITKKC
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Rana rugosa
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A498 | Renal cell carcinoma | Carcinoma | IC50=138.06 µg/ml | MTT assay | 3 days | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=145.72 µg/ml | MTT assay | 3 days | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=113.31 µg/ml | MTT assay | 3 days | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=183.74 µg/ml | MTT assay | 3 days | 1 |
| MKN 45 | Gastric adenocarcinoma | Carcinoma | IC50=34.96 µg/ml | MTT assay | 3 days | 1 |
| NCI-H630 | Rectal carcinoma | Carcinoma | IC50=41.85 µg/ml | MTT assay | 3 days | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=43.64 µg/ml | MTT assay | 3 days | 1 |
| SK-MEL-2 | Melanoma | Carcinoma | IC50=47.47 µg/ml | MTT assay | 3 days | 1 |
| SK-OV-3 | Ovarian serous cystadenocarcinoma | Carcinoma | IC50=38.28 µg/ml | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: 7% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C119H203N29O28S2
Absent amino acids DEHMNQRWY
Common amino acids K
Mass 296266
Pl 10.63
Basic residues 5
Acidic residues 0
Hydrophobic residues 12
Net charge 5
Boman Index 957
Hydrophobicity 86.25
Aliphatic Index 113.75
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 5.43
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16884301
Title Structural determinants for the membrane interaction of novel bioactive undecapeptides derived from gaegurin 5
Year 2006
Literature 2
Pubmed ID 14739294
Title Systematic peptide engineering and structural characterization to search for the shortest antimicrobial peptide analogue of gaegurin 5
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.