This work is licensed under a Creative Commons Attribution 4.0 International License.
Gaegurin 5 (1-11)[V8W]
General Information
DRACP ID DRACP00168
Peptide Name Gaegurin 5 (1-11)[V8W]
Sequence FLGALFKWASK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A498 | Renal cell carcinoma | Carcinoma | IC50=214.33 µg/ml | MTT assay | 3 days | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=418.15 µg/ml | MTT assay | 3 days | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=144.37 µg/ml | MTT assay | 3 days | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=198.87 µg/ml | MTT assay | 3 days | 1 |
| MKN 45 | Gastric adenocarcinoma | Carcinoma | IC50=142.72 µg/ml | MTT assay | 3 days | 1 |
| NCI-H630 | Rectal carcinoma | Carcinoma | IC50=129.54 µg/ml | MTT assay | 3 days | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=174.15 µg/ml | MTT assay | 3 days | 1 |
| SK-OV-3 | Ovarian serous cystadenocarcinoma | Carcinoma | IC50=150.45 µg/m | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: 7% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity MCF-10a: IC50=434.79 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C64H94N14O13
Absent amino acids CDEHIMNPQRTVY
Common amino acids AFKL
Mass 144609
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 7
Net charge 2
Boman Index 819
Hydrophobicity 62.73
Aliphatic Index 89.09
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 550
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16884301
Title Structural determinants for the membrane interaction of novel bioactive undecapeptides derived from gaegurin 5
Year 2006
Literature 2
Pubmed ID 14739294
Title Systematic peptide engineering and structural characterization to search for the shortest antimicrobial peptide analogue of gaegurin 5
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.