Gaegurin 5 (1-11)[V8W]

General Information


DRACP ID  DRACP00168

Peptide Name   Gaegurin 5 (1-11)[V8W]

Sequence  FLGALFKWASK

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A498 Renal cell carcinoma Carcinoma IC50=214.33 µg/ml MTT assay 3 days 1
A549 Lung adenocarcinoma Carcinoma IC50=418.15 µg/ml MTT assay 3 days 1
HCT 116 Colon carcinoma Carcinoma IC50=144.37 µg/ml MTT assay 3 days 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=198.87 µg/ml MTT assay 3 days 1
MKN 45 Gastric adenocarcinoma Carcinoma IC50=142.72 µg/ml MTT assay 3 days 1
NCI-H630 Rectal carcinoma Carcinoma IC50=129.54 µg/ml MTT assay 3 days 1
PC-3 Prostate carcinoma Carcinoma IC50=174.15 µg/ml MTT assay 3 days 1
SK-OV-3 Ovarian serous cystadenocarcinoma Carcinoma IC50=150.45 µg/m MTT assay 3 days 1

Hemolytic Activity  Human erythrocytes: 7% Hemolysis=100 µg/ml

Normal (non-cancerous) Cytotoxicity  MCF-10a: IC50=434.79 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00168

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C64H94N14O13

Absent amino acids  CDEHIMNPQRTVY

Common amino acids  AFKL

Mass  144609

Pl  10.81

Basic residues  2

Acidic residues  0

Hydrophobic residues  7

Net charge  2

Boman Index  819

Hydrophobicity  62.73

Aliphatic Index  89.09

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  5500

Absorbance 280nm  550

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 16884301

Title  Structural determinants for the membrane interaction of novel bioactive undecapeptides derived from gaegurin 5

Doi 10.1021/jm050996u

Year  2006

Literature 2

Pubmed ID 14739294

Title  Systematic peptide engineering and structural characterization to search for the shortest antimicrobial peptide analogue of gaegurin 5

Doi 10.1074/jbc.M309822200

Year  2004

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.