This work is licensed under a Creative Commons Attribution 4.0 International License.
Gaegurin 5 (1-11)[A4W]
General Information
DRACP ID DRACP00169
Peptide Name Gaegurin 5 (1-11)[A4W]
Sequence FLGWLFKVASK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A498 | Renal cell carcinoma | Carcinoma | IC50=73.26 µg/ml | MTT assay | 3 days | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=106.27 µg/ml | MTT assay | 3 days | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=30.48 µg/ml | MTT assay | 3 days | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=77.29 µg/ml | MTT assay | 3 days | 1 |
| MKN 45 | Gastric adenocarcinoma | Carcinoma | IC50=82.70 µg/ml | MTT assay | 3 days | 1 |
| NCI-H630 | Rectal carcinoma | Carcinoma | IC50=75.92 µg/ml | MTT assay | 3 days | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=123.81 µg/ml | MTT assay | 3 days | 1 |
| SK-MEL-2 | Melanoma | Carcinoma | IC50=30.48 µg/ml | MTT assay | 3 days | 1 |
| SK-OV-3 | Ovarian serous cystadenocarcinoma | Carcinoma | IC50=92.15 µg/ml | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: 12% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity MCF-10a: IC50=311.38 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C66H98N14O13
Absent amino acids CDEHIMNPQRTY
Common amino acids FKL
Mass 147414
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 7
Net charge 2
Boman Index 1042
Hydrophobicity 84.55
Aliphatic Index 106.36
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 550
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16884301
Title Structural determinants for the membrane interaction of novel bioactive undecapeptides derived from gaegurin 5
Year 2006
Literature 2
Pubmed ID 14739294
Title Systematic peptide engineering and structural characterization to search for the shortest antimicr
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.