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Brevinin-Alb
General Information
DRACP ID DRACP00170
Peptide Name Brevinin-Alb
Sequence FLPLAVSLAANFLPKLFCKITKKC
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Amolops loloensis; Amolops jingdongensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | IC50=58 µg/ml | MTT assay | 48h | 1 |
Hemolytic Activity Rabbit erythrocytes: 50% Hemolysis=5 µg/ml; 96% Hemolysis=20 µg/ml
Normal (non-cancerous) Cytotoxicity Rat mast cells: 17% degranulation=100 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C128H209N29O28S2
Absent amino acids DEGHMQRWY
Common amino acids L
Mass 307681
Pl 10.35
Basic residues 4
Acidic residues 0
Hydrophobic residues 13
Net charge 4
Boman Index 1568
Hydrophobicity 94.58
Aliphatic Index 122.08
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 5.43
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17000029
Title Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis
Doi 10.1016/j.peptides.2006.08.017
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.