Peptide Libraray

Cytotoxin drCT-1 (drCT-I)

General Information

DRACP ID DRACP00171

Peptide Name Cytotoxin drCT-1 (drCT-I)

Sequence LKCNKLVPLFYKTCPAGKNL

Sequence Length 20

UniProt ID P0C5H4

PubChem CID Not available

Origin Daboia russelii (Russel's viper) (Vipera russelii)

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
U-937	Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia	Leukemia	IC50=8.9μg/ml	MTT assay	24h	1
K562	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia	Leukemia	IC50=6.7μg/ml	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure DRACP00171

Helicity Not available

Linear/Cyclic Not available

Disulfide/Other Bond Not available

N-terminal Modification Not available

C-terminal Modification Not available

Other Modification None

Chiral L

Physicochemical Information

Formula C104H172N26O25S2

Absent amino acids DEHIMQRSW

Common amino acids KL

Mass 258988

Pl 10.06

Basic residues 4

Acidic residues 0

Hydrophobic residues 7

Net charge 4

Boman Index -618

Hydrophobicity 4

Aliphatic Index 97.5

Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 1615

Absorbance 280nm 85

Polar residues 7

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 17055549

Title A heat stable protein toxin (drCT-I) from the Indian Viper (Daboia russelli russelli) venom having antiproliferative, cytotoxic and apoptotic activities

Doi 10.1016/j.toxicon.2006.09.009

Year 2006

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available