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Magainin A
General Information
DRACP ID DRACP00174
Peptide Name Magainin A
Sequence AIGKFLHSAKKFGKAFVGEIMNS
Sequence Length 23
PubChem CID Not available
Origin Xenopus laevis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | IC50=16 µg/ml | Trypan blue assay | 72 h | 1 |
| RPMI-8402 | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | leukemia | IC50=18 µg/ml | Trypan blue assay | 72 h | 1 |
| SSKT-1 | Leukemia | Leukemia | IC50=23 µg/ml | Trypan blue assay | 72 h | 1 |
| Daudi | EBV-related Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=30 µg/ml | Trypan blue assay | 72 h | 1 |
| MLA | Leukemia | Leukemia | IC50=34 µg/ml | Trypan blue assay | 72 h | 1 |
| Raji | EBV-related Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=20 µg/ml | Trypan blue assay | 72 h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=40 µg/ml | Trypan blue assay | 72 h | 1 |
| CHP-100 | Ewing sarcoma | Sarcoma | IC50=45 µg/ml | Trypan blue assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=49 µg/ml | Trypan blue assay | 72 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=53 µg/ml | Trypan blue assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism magainin 2 and synthetic analogues can rapidly and irreversibly lyse hematopoietic tumor and solid tumor
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Beta-alanine
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C115H182N30O29S
Absent amino acids CDPQRTWY
Common amino acids K
Mass 287355
Pl 10.8
Basic residues 5
Acidic residues 1
Hydrophobic residues 10
Net charge 4
Boman Index -877
Hydrophobicity 17.83
Aliphatic Index 76.52
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 1708887
Title Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation
Year 1990
Literature 2
Pubmed ID 2285300
Title Magainin analogs effective against pathogenic protozoa
Year 1990
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.