This work is licensed under a Creative Commons Attribution 4.0 International License.
Z44
General Information
DRACP ID DRACP00175
Peptide Name Z44
Sequence ALSKALSKALSKALSKALSKALSK
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Xenopus laevis
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | IC50=97 µg/ml | Trypan blue assay | 72 h | 1 |
| RPMI-8402 | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | leukemia | IC50=60 µg/ml | Trypan blue assay | 72 h | 1 |
| SSKT-1 | Leukemia | Leukemia | IC50=107 µg/ml | Trypan blue assay | 72 h | 1 |
| Daudi | EBV-related Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=115 µg/ml | Trypan blue assay | 72 h | 1 |
| MLA | Leukemia | Leukemia | IC50=80 µg/ml | Trypan blue assay | 72 h | 1 |
| Raji | EBV-related Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=64 µg/ml | Trypan blue assay | 72 h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=98 µg/ml | Trypan blue assay | 72 h | 1 |
| CHP-100 | Ewing sarcoma | Sarcoma | Not available | Trypan blue assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | Not available | Trypan blue assay | 72 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | Not available | Trypan blue assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism magainin 2 and synthetic analogues can rapidly and irreversibly lyse hematopoietic tumor and solid tumor
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C108H200N30O31
Absent amino acids CDEFGHIMNPQRTVWY
Common amino acids AKLS
Mass 282540
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 12
Net charge 6
Boman Index -1332
Hydrophobicity 22.5
Aliphatic Index 122.5
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 1708887
Title Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation
Year 1990
Literature 2
Pubmed ID 2285300
Title Magainin analogs effective against pathogenic protozoa
Year 1990
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.