Z24

General Information


DRACP ID  DRACP00176

Peptide Name   Z24

Sequence  ALSKALSKALSKALSKALSKALSK

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  Xenopus laevis

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
U-937 Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia Leukemia IC50=123 µg/ml Trypan blue assay 72 h 1
RPMI-8402 Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia leukemia IC50=83 µg/ml Trypan blue assay 72 h 1
SSKT-1 Leukemia Leukemia IC50=109 µg/ml Trypan blue assay 72 h 1
Daudi EBV-related Burkitt lymphoma; Burkitt lymphoma Lymphoma IC50=143 µg/ml Trypan blue assay 72 h 1
MLA Leukemia Leukemia IC50=102 µg/ml Trypan blue assay 72 h 1
Raji EBV-related Burkitt lymphoma; Burkitt lymphoma Lymphoma IC50=72 µg/ml Trypan blue assay 72 h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia Leukemia IC50=112 µg/ml Trypan blue assay 72 h 1
CHP-100 Ewing sarcoma Sarcoma Not available Trypan blue assay 72 h 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma Not available Trypan blue assay 72 h 1
PC-3 Prostate carcinoma Carcinoma Not available Trypan blue assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  magainin 2 and synthetic analogues can rapidly and irreversibly lyse hematopoietic tumor and solid tumor

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00176

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C108H200N30O31

Absent amino acids  CDEFGHIMNPQRTVWY

Common amino acids  AKLS

Mass  282540

Pl  11.5

Basic residues  6

Acidic residues  0

Hydrophobic residues  12

Net charge  6

Boman Index  -1332

Hydrophobicity  22.5

Aliphatic Index  122.5

Half Life 
  Mammalian: 4.4 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 1708887

Title  Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation

Doi 10.1073/pnas.88.9.3792

Year  1990

Literature 2

Pubmed ID 2285300

Title  Magainin analogs effective against pathogenic protozoa

Doi 10.1128/AAC.34.9.1824

Year  1990

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.