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Odorranain-C1
General Information
DRACP ID DRACP00178
Peptide Name Odorranain-C1
Sequence GVLGAVKDLLIGAGKSAAQSVLKTLSCKLSNDC
Sequence Length 33
UniProt ID Not available
PubChem CID Not available
Origin Odorrana grahami
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=27.31 µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=41.21 µM | MTT assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=52.83 µM | MTT assay | 24h | 1 |
| LoVo | Colon adenocarcinoma | Carcinoma | IC50=55.22 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 0% Hemolysis=50 µg/ml; Sheep erythrocytes: <10% Hemolysis=256 µM
Normal (non-cancerous) Cytotoxicity Human mast cells: 2.9±1.5% degranulation=50 µg/ml; HEK293T: IC50=48.7 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys27<--->Cys33
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C140H247N39O45S2
Absent amino acids EFHMPRWY
Common amino acids L
Mass 383186
Pl 8.81
Basic residues 4
Acidic residues 2
Hydrophobic residues 14
Net charge 2
Boman Index -787
Hydrophobicity 51.52
Aliphatic Index 121.21
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 3.91
Polar residues 12
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34073203
Title Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides
Year 2021
Literature 2
Pubmed ID 17272268
Title Anti-infection peptidomics of amphibian skin
Doi 10.1074/mcp.M600334-MCP200
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.