This work is licensed under a Creative Commons Attribution 4.0 International License.
C7S/NK27
General Information
DRACP ID DRACP00180
Peptide Name C7S/NK27
Sequence KILRGVSKKIMRTFLRRISKDILTGKK
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | (38.4±10.3)% Cytotoxicity=100 µg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 25% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C143H261N45O34S
Absent amino acids ACEHNPQWY
Common amino acids K
Mass 365092
Pl 12.55
Basic residues 10
Acidic residues 1
Hydrophobic residues 9
Net charge 9
Boman Index -6795
Hydrophobicity -38.52
Aliphatic Index 111.85
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17389605
Title Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.