This work is licensed under a Creative Commons Attribution 4.0 International License.
NK23a
General Information
DRACP ID DRACP00182
Peptide Name NK23a
Sequence KISKKIMRTFLRRISKDILTGKK
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Not active up to 100 µg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C124H226N38O30S
Absent amino acids ACEHNPQVWY
Common amino acids K
Mass 315404
Pl 12.31
Basic residues 9
Acidic residues 1
Hydrophobic residues 7
Net charge 8
Boman Index -6293
Hydrophobicity -58.7
Aliphatic Index 101.74
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17389605
Title Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.