This work is licensed under a Creative Commons Attribution 4.0 International License.
Phylloseptin-L1
General Information
DRACP ID DRACP00186
Peptide Name Phylloseptin-L1
Sequence LLGMIPLAISAISALSKL
Sequence Length 18
UniProt ID A0A5Q0MU22 P0DQK9 L0P329
PubChem CID Not available
Origin skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | LC50=35 μM | Cytolytic assays | 1 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=200 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Cytolytic
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C84H151N19O22S
Absent amino acids CDEFHNQRTVWY
Common amino acids L
Mass 211473
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 11
Net charge 1
Boman Index 3233
Hydrophobicity 175
Aliphatic Index 190
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17561225
Title Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
Doi 10.1016/j.toxicon.2007.04.017
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.