This work is licensed under a Creative Commons Attribution 4.0 International License.
Arenicin-1
General Information
DRACP ID DRACP00187
Peptide Name Arenicin-1
Sequence RWCVYAYVRVRGVLVRYRRCW
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Arenicola marina
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | LD50=4 µM | Alamar blue assay | 30 min | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL11 positive; Chronic myeloid leukemia | Leukemia | IC50=17.9 µM | MTT assay | 24h | 2 |
Hemolytic Activity Human erythrocytes: 0% Hemolysis=12.5 µM; 12% Hemolysis=25 µM; 35% Hemolysis=50 µM; 51% Hemolysis=100 µM; 10% Hemolysis=4.1 µM; 15% Hemolysis=10.3 µM; 50% Hemolysis=66.3 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Cys3<--->Cys20
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C127H195N41O25S2
Absent amino acids DEFHIKMNPQST
Common amino acids R
Mass 311723
Pl 11.15
Basic residues 6
Acidic residues 0
Hydrophobic residues 9
Net charge 6
Boman Index -5485
Hydrophobicity -7.14
Aliphatic Index 92.38
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 15595
Absorbance 280nm 779.75
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17935487
Title Structure and mode of action of the antimicrobial peptide arenicin
Year 2008
Literature 2
Pubmed ID 31234579
Title Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization
Year 2019
Literature 3
Pubmed ID 21241661
Title The characteristic region of arenicin-1 involved with a bacterial membrane targeting mechanism
Doi 10.1016/j.bbrc.2011.01.046
Year 2011
Literature 4
Pubmed ID 25557880
Title Design of antimicrobial peptide arenicin analogs with improved therapeutic indices
Doi 10.1002/psc.2732
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.