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Pep1
General Information
DRACP ID DRACP00194
Peptide Name Pep1
Sequence FKCRRWQWRMKKLGAPSITCVR
Sequence Length 22
UniProt ID P24627
PubChem CID Not available
Origin Bovine lactoferrin (Lf-B)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50=77 µM | MTS assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Pep1 may kill cancer cells by activating an apoptosis-inducing pathway
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C123H200N40O26S3
Absent amino acids DEHNY
Common amino acids R
Mass 312612
Pl 12.1
Basic residues 7
Acidic residues 0
Hydrophobic residues 7
Net charge 7
Boman Index -5866
Hydrophobicity -65.91
Aliphatic Index 53.18
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11125
Absorbance 280nm 529.76
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18425992
Title A lactoferrin-derived peptide with cationic residues concentrated in a region of its helical structure induces necrotic cell death in a leukemic cell line (HL-60)
Doi 10.1002/psc.1039
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.