This work is licensed under a Creative Commons Attribution 4.0 International License.
a5
General Information
DRACP ID DRACP00198
Peptide Name a5
Sequence KAQIRAMECNIL
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Cyclin B (285-296)
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HCT 116 | Colon carcinoma | Carcinoma | Not available | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C58H104N18O17S2
Absent amino acids DFGHPSTVWY
Common amino acids AI
Mass 158610
Pl 8.55
Basic residues 2
Acidic residues 1
Hydrophobic residues 5
Net charge 1
Boman Index -1745
Hydrophobicity 15.83
Aliphatic Index 114.17
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18656352
Title A novel peptide from alpha5 helix of Asterina pectinifera cyclin B conjugated to HIV-Tat(49-57) with cytotoxic and apoptotic effects against human cancer cells
Doi 10.1016/j.bmcl.2008.07.017
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.