Peptide Libraray

di-PST13-RK-C

General Information

DRACP ID DRACP00201

Peptide Name di-PST13-RK-C

Sequence KKKFPWWWPFKKKCKKKFPWWWPFKKKC

Sequence Length 28

UniProt ID Not available

PubChem CID Not available

Origin Derivative of tritrpticin

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Carcinoma	IC50=17 µg/ml	MTT assay	Not available	1
MDA-MB-361	Breast adenocarcinoma	Carcinoma	IC50=17 µg/ml	MTT assay	Not available	1
A549	Lung adenocarcinoma	Carcinoma	IC50=15 µg/ml	MTT assay	Not available	1
MDA-MB-361	Breast adenocarcinoma	Carcinoma	IC50=10 µg/ml	MTT assay	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity NIH-3T3 (mouse): IC50=20 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00201

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C200H280N46O29S2

Absent amino acids ADEGHILMNQRSTVY

Common amino acids K

Mass 433858

Pl 11.28

Basic residues 12

Acidic residues 0

Hydrophobic residues 10

Net charge 12

Boman Index -3814

Hydrophobicity -151.43

Aliphatic Index 0

Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 33125

Absorbance 280nm 1226.85

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 18815734

Title Effect of dimerization of a beta-turn antimicrobial peptide, PST13-RK, on antimicrobial activity and mammalian cell toxicity

Doi 10.1007/s10529-008-9848-5

Year 2009

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available