This work is licensed under a Creative Commons Attribution 4.0 International License.
Tritrpticin
General Information
DRACP ID DRACP00202
Peptide Name Tritrpticin
Sequence VRRFPWWWPFLRR
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Derivative of tritrpticin
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50>200 µg/ml | MTT assay | Not available | 1 |
| MDA-MB-361 | Breast adenocarcinoma | Carcinoma | IC50=142 µg/ml | MTT assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH-3T3 (mouse): IC50=145 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C96H132N28O14
Absent amino acids ACDEGHIKMNQSTY
Common amino acids R
Mass 211648
Pl 12.98
Basic residues 4
Acidic residues 0
Hydrophobic residues 7
Net charge 4
Boman Index -3777
Hydrophobicity -79.23
Aliphatic Index 52.31
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 16500
Absorbance 280nm 1375
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18815734
Title Effect of dimerization of a beta-turn antimicrobial peptide, PST13-RK, on antimicrobial activity and mammalian cell toxicity
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.