This work is licensed under a Creative Commons Attribution 4.0 International License.
PNC-28
General Information
DRACP ID DRACP00203
Peptide Name PNC-28
Sequence ETFSDLWKLL
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Antennapedia
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Mia PaCa-2 | Pancreatic ductal adenocarcinoma | Carcinoma | Cytotoxicity=80% μmol/ml | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism PNC-28 may be effective in treating human pancreatic cancer. The penetratin sequence appears to be responsible for the fundamental change in the mechanism of action, inducing rapid necrosis initiated by membrane pore formation.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C60H90N12O17
Absent amino acids ACGHIMNPQRVY
Common amino acids L
Mass 141216
Pl 4.18
Basic residues 1
Acidic residues 2
Hydrophobic residues 5
Net charge -1
Boman Index -698
Hydrophobicity 9
Aliphatic Index 117
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 611.11
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18931881
Title The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.