This work is licensed under a Creative Commons Attribution 4.0 International License.
Crotamine (1–9,38–42)
General Information
DRACP ID DRACP00204
Peptide Name Crotamine (1–9,38–42)
Sequence YKQCHKKGGKKGSG
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Not active up to 100 µM | MTT assay | 4h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>300µM
Normal (non-cancerous) Cytotoxicity PBMC: IC50>300µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C64H108N22O18S
Absent amino acids ADEFILMNPRTVW
Common amino acids K
Mass 173782
Pl 10.7
Basic residues 6
Acidic residues 0
Hydrophobic residues 0
Net charge 6
Boman Index -3645
Hydrophobicity -195.71
Aliphatic Index 0
Half Life
Mammalian: 1 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 114.62
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18983137
Title A novel cell-penetrating peptide sequence derived by structural minimization of a snake toxin exhibits preferential nucleolar localization
Year 2008
Literature 2
Pubmed ID 28314993
Title Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.