This work is licensed under a Creative Commons Attribution 4.0 International License.
Brevinin-1BLa
General Information
DRACP ID DRACP00205
Peptide Name Brevinin-1BLa
Sequence FLPAIVGAAAKFLPKIFCAISKKC
Sequence Length 24
UniProt ID A7YJF9
PubChem CID Not available
Origin North America, leopard frog, Lithobates blairi
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | LD50=12 μM | Cytolytic assays | Not available | 1 |
Hemolytic Activity Human erythrocytes: LD50=14 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism potent cytolytic activity
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H198N28O26S2
Absent amino acids DEHMNQRTWY
Common amino acids A
Mass 294766
Pl 10.35
Basic residues 4
Acidic residues 0
Hydrophobic residues 14
Net charge 4
Boman Index 2453
Hydrophobicity 115.42
Aliphatic Index 114.17
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 5.43
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19254736
Title Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis
Doi 10.1016/j.toxicon.2009.02.018
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4213
This work is licensed under a Creative Commons Attribution 4.0 International License.