This work is licensed under a Creative Commons Attribution 4.0 International License.
Brevinin-1Ya
General Information
DRACP ID DRACP00207
Peptide Name Brevinin-1Ya
Sequence FLPVIAGVAANFLPKLFCAISKKC
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin North America, leopard frog, Lithobates blairi
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | LD50=16 μM | Cytolytic assays | Not available | 1 |
Hemolytic Activity Human erythrocytes: LD50=18 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism potent cytolytic activity
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H196N28O27S2
Absent amino acids DEHMQRTWY
Common amino acids A
Mass 296164
Pl 9.67
Basic residues 3
Acidic residues 0
Hydrophobic residues 14
Net charge 3
Boman Index 2567
Hydrophobicity 124.17
Aliphatic Index 122.08
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 5.43
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19254736
Title Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis
Doi 10.1016/j.toxicon.2009.02.018
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4215
This work is licensed under a Creative Commons Attribution 4.0 International License.