This work is licensed under a Creative Commons Attribution 4.0 International License.
Brevinin-1Yb
General Information
DRACP ID DRACP00208
Peptide Name Brevinin-1Yb
Sequence FLPIIAGAAAKVVQKIFCAISKKC
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin North America, leopard frog, Lithobates blairi
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | LD50=11 μM | Cytolytic assays | Not available | 1 |
Hemolytic Activity Human erythrocytes: LD50=16 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism potent cytolytic activity
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C118H199N29O27S2
Absent amino acids DEHMNRTWY
Common amino acids A
Mass 293064
Pl 10.35
Basic residues 4
Acidic residues 0
Hydrophobic residues 14
Net charge 4
Boman Index 2005
Hydrophobicity 116.25
Aliphatic Index 126.25
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 5.43
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19254736
Title Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis
Doi 10.1016/j.toxicon.2009.02.018
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4216
This work is licensed under a Creative Commons Attribution 4.0 International License.