Brevinin-1Yc

General Information


DRACP ID  DRACP00209

Peptide Name   Brevinin-1Yc

Sequence  FLPIIAGAAAKVVEKIFCAISKKC

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  North America, leopard frog, Lithobates blairi

Type  Native peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Hep-G2 Hepatoblastoma; Hepatoblastoma Blastoma LD50=14 μM Cytolytic assays Not available 1

Hemolytic Activity  Human erythrocytes: LD50=13 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  potent cytolytic activity

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00209

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Cys18<--->Cys24

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C118H198N28O28S2

Absent amino acids  DHMNQRTWY

Common amino acids  A

Mass  293162

Pl  9.6

Basic residues  4

Acidic residues  1

Hydrophobic residues  14

Net charge  3

Boman Index  1878

Hydrophobicity  116.25

Aliphatic Index  126.25

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  125

Absorbance 280nm  5.43

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 19254736

Title  Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis

Doi 10.1016/j.toxicon.2009.02.018

Year  2009

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_4217

DRACP is developed by Dr.Zheng's team.