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Ranatuerin-2Ya
General Information
DRACP ID DRACP00210
Peptide Name Ranatuerin-2Ya
Sequence GLMDTIKGVAKTVAASWLDKLKCKITGC
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin North America, leopard frog, Lithobates yavapaiensis
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | LD50=20 μM | Cytolytic assays | Not available | 1 |
Hemolytic Activity Human erythrocytes: LD50>100 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism potent cytolytic activity
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Cys23<--->Cys28
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C130H224N34O37S3
Absent amino acids EFHNPQRY
Common amino acids K
Mass 343341
Pl 9.55
Basic residues 5
Acidic residues 2
Hydrophobic residues 11
Net charge 3
Boman Index -813
Hydrophobicity 34.29
Aliphatic Index 101.07
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5625
Absorbance 280nm 208.33
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19254736
Title Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis
Doi 10.1016/j.toxicon.2009.02.018
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4218
This work is licensed under a Creative Commons Attribution 4.0 International License.