This work is licensed under a Creative Commons Attribution 4.0 International License.
Brevinin-1 CEa
General Information
DRACP ID DRACP00211
Peptide Name Brevinin-1 CEa
Sequence FLIGMTQGLICLITRKC
Sequence Length 17
UniProt ID P0C5X0
PubChem CID Not available
Origin skin of the Chinese brown frog, Rana chensinensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=54 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: LD50=48 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C85H148N22O21S3
Absent amino acids ADEHNPSVWY
Common amino acids IL
Mass 219602
Pl 8.83
Basic residues 2
Acidic residues 0
Hydrophobic residues 7
Net charge 2
Boman Index 814
Hydrophobicity 120.59
Aliphatic Index 137.65
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 7.81
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19341344
Title Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.