This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-CEb
General Information
DRACP ID DRACP00213
Peptide Name Temporin-CEb
Sequence ILPILSLIGGLL
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin skin of the Chinese brown frog, Rana chensinensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=56 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: LD50=112 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C60H108N12O14
Absent amino acids ACDEFHKMNQRTVWY
Common amino acids L
Mass 141800
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 8
Net charge 0
Boman Index 3784
Hydrophobicity 244.17
Aliphatic Index 260
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19341344
Title Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.