Temporin-CEb

General Information


DRACP ID  DRACP00213

Peptide Name   Temporin-CEb

Sequence  ILPILSLIGGLL

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  skin of the Chinese brown frog, Rana chensinensis

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=56 µM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: LD50=112 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00213

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C60H108N12O14

Absent amino acids  ACDEFHKMNQRTVWY

Common amino acids  L

Mass  141800

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  8

Net charge  0

Boman Index  3784

Hydrophobicity  244.17

Aliphatic Index  260

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 19341344

Title  Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis

Doi 10.2108/zsj.26.220

Year  2009

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.