This work is licensed under a Creative Commons Attribution 4.0 International License.
Chensinin-1
General Information
DRACP ID DRACP00214
Peptide Name Chensinin-1
Sequence SAVGRHGRRFGLRKHRKH
Sequence Length 18
UniProt ID B5A9T1
PubChem CID Not available
Origin skin of the Chinese brown frog, Rana chensinensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>200 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: LD50>500 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C92H155N41O20
Absent amino acids CDEIMNPQTWY
Common amino acids R
Mass 245890
Pl 13.11
Basic residues 10
Acidic residues 0
Hydrophobic residues 4
Net charge 10
Boman Index -8651
Hydrophobicity -162.78
Aliphatic Index 43.33
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19341344
Title Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.