This work is licensed under a Creative Commons Attribution 4.0 International License.
Malanin chain A
General Information
DRACP ID DRACP00215
Peptide Name Malanin chain A
Sequence DYPKLTFTTS
Sequence Length 10
UniProt ID P86600
PubChem CID Not available
Origin Malania oleifera
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=0.15±0.08nM | MTT assay | 72h | 1 |
| PC-12 | Lung papillary adenocarcinoma | Carcinoma | IC50=7.71±0.24nM | MTT assay | 72h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=11.20±0.02nM | MTT assay | 72h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=15.80±0.09nM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Vero: IC50=2.79±0.05nM; MDCK: IC50=3.92±0.01nM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Not available
C-terminal Modification Not available
Other Modification None
Chiral L
Physicochemical Information
Formula C54H81N11O18
Absent amino acids ACEGHIMNQRVW
Common amino acids T
Mass 133300
Pl 6.34
Basic residues 1
Acidic residues 1
Hydrophobic residues 2
Net charge 0
Boman Index -1762
Hydrophobicity -66
Aliphatic Index 39
Half Life
Mammalian: 1.9 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19341757
Title Purification, characterization and cytotoxicity of malanin, a novel plant toxin from the seeds of Malania oleifera
Doi 10.1016/j.toxicon.2009.03.024
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.