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Malanin chain B
General Information
DRACP ID DRACP00216
Peptide Name Malanin chain B
Sequence DETXTDEEFN
Sequence Length 10
UniProt ID P86601
PubChem CID Not available
Origin Malania oleifera
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=0.15±0.08nM | MTT assay | 72h | 1 |
| PC-12 | Lung papillary adenocarcinoma | Carcinoma | IC50=7.71±0.24nM | MTT assay | 72h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=11.20±0.02nM | MTT assay | 72h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=15.80±0.09nM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Vero: IC50=2.79±0.05nM; MDCK: IC50=3.92±0.01nM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Not available
C-terminal Modification Not available
Other Modification None
Chiral L
Physicochemical Information
Formula C44H60N10O22
Absent amino acids ACGHIKLMPQRSVWY
Common amino acids E
Mass 135172
Pl 3.23
Basic residues 0
Acidic residues 5
Hydrophobic residues 1
Net charge -5
Boman Index -4667
Hydrophobicity -196
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19341757
Title Purification, characterization and cytotoxicity of malanin, a novel plant toxin from the seeds of Malania oleifera
Doi 10.1016/j.toxicon.2009.03.024
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.