This work is licensed under a Creative Commons Attribution 4.0 International License.
Cathelicidin-1 (8-26), CATH-1 (8-26), Fowlicidin-1 (8-26)
General Information
DRACP ID DRACP00217
Peptide Name Cathelicidin-1 (8-26), CATH-1 (8-26), Fowlicidin-1 (8-26)
Sequence LVIRTVIAGYNLYRAIKKK
Sequence Length 19
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse macrophage leukemia cell | Leukemia | Not active up to 16 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>360 µM; Sheep erythrocytes: 10% Hemolysis=240 µM
Normal (non-cancerous) Cytotoxicity Madin-Darby canine kidney cells: 50% Cell death=159 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C104H179N29O24
Absent amino acids CDEFHMPQSW
Common amino acids IK
Mass 254100
Pl 11.15
Basic residues 5
Acidic residues 0
Hydrophobic residues 9
Net charge 5
Boman Index -1874
Hydrophobicity 27.37
Aliphatic Index 143.68
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 2980
Absorbance 280nm 165.56
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31473417
Title The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities
Doi 10.1016/j.ejmech.2019.111623
Year 2019
Literature 2
Pubmed ID 16817888
Title Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken
Doi 10.1111/j.1742-4658.2006.05261.x
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_775
This work is licensed under a Creative Commons Attribution 4.0 International License.