This work is licensed under a Creative Commons Attribution 4.0 International License.
LfcinB
General Information
DRACP ID DRACP00218
Peptide Name LfcinB
Sequence FKCRRWQWRMKK
Sequence Length 12
UniProt ID P24627
PubChem CID Not available
Origin Bovine lactoferrin (Lf-B)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| FEMX-I | Melanoma | Carcinoma | IC50=40±7 µM | MTT assay | 24 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=148±8 µM | MTT assay | 24 h | 1 |
| KMS-5 | Plasma cell myeloma; Multiple myeloma | Carcinoma | IC50=38 µM | MTT assay | 24 h | 1 |
| U266B1 | Plasma cell myeloma; Multiple myeloma | Carcinoma | IC50=55 µM | MTT assay | 24 h | 1 |
| KMM-1 | Plasma cell myeloma; Multiple myeloma | Carcinoma | IC50=57 µM | MTT assay | 24 h | 1 |
| SU-DHL-4 | Diffuse large B-cell lymphoma germinal center B-cell type; Diffuse large B-cell lymphoma | Lymphoma | IC50=16 µM | MTT assay | 24 h | 1 |
| Raji | EBV-related Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=13 µM | MTT assay | 24 h | 1 |
| Ramos | Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=10 µM | MTT assay | 24 h | 1 |
| MT-1 | Human mammary carcinoma | Carcinoma | IC50>160 µM | MTT assay | 30 min | 2 |
| Kelly | Neuroblastoma | Blastoma | IC50=141 ± 3 µM | MTT assay | 30 min | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Peptides induce lysis of cancer cells through interactions with the plasma membrane
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C80H125N27O14S2
Absent amino acids ADEGHILNPSTVY
Common amino acids KR
Mass 194954
Pl 12.26
Basic residues 6
Acidic residues 0
Hydrophobic residues 3
Net charge 6
Boman Index -5568
Hydrophobicity -194.17
Aliphatic Index 0
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: >10 hour
Extinction Coefficient cystines 11000
Absorbance 280nm 1000
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19527490
Title The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells
Year 2009
Literature 2
Pubmed ID 21453492
Title Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.