This work is licensed under a Creative Commons Attribution 4.0 International License.
KW5
General Information
DRACP ID DRACP00219
Peptide Name KW5
Sequence KAAKKAAKAAKKAAKAAKKAA
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Bovine lactoferrin (Lf-B)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| FEMX-I | Melanoma | Carcinoma | IC50=30±3 µM | MTT assay | 30 min | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=55±14 µM | MTT assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Peptides induce lysis of cancer cells through interactions with the plasma membrane
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C90H170N30O22
Absent amino acids CDEFGHILMNPQRSTVWY
Common amino acids A
Mass 238149
Pl 11.7
Basic residues 9
Acidic residues 0
Hydrophobic residues 12
Net charge 9
Boman Index -2823
Hydrophobicity -64.29
Aliphatic Index 57.14
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19527490
Title The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.