This work is licensed under a Creative Commons Attribution 4.0 International License.
Polybia-MPI [L14L-S]
General Information
DRACP ID DRACP00220
Peptide Name Polybia-MPI [L14L-S]
Sequence IDWKKLLDAAKQIX
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | IC50=21.2±0.8µM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=20.3±1.0µM | MTT assay | 24h | 1 |
| EJ | Endometrial Adenocarcinoma | Carcinoma | IC50=21.6±1.2µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: 50% Cell death>60 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=Leu-S
Chiral L
Physicochemical Information
Formula C72H118N18O18
Absent amino acids CEFGHMNPRSTVY
Common amino acids K
Mass 186593
Pl 9.44
Basic residues 3
Acidic residues 2
Hydrophobic residues 7
Net charge 1
Boman Index -1400
Hydrophobicity -20.71
Aliphatic Index 125.71
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 423.08
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20600424
Title A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice.
Doi 10.1016/j.peptides.2010.06.019
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.