This work is licensed under a Creative Commons Attribution 4.0 International License.
Ltc-5 [M6R]
General Information
DRACP ID DRACP00221
Peptide Name Ltc-5 [M6R]
Sequence GFFGKRKEYFKKFGASFKRRFANLKKRL
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL7 positive; Chronic myeloid leukemia | Leukemia | EC50>36 µM | Hoechst 33342 and PI assay | 3h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>36 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C165H256N48O34
Absent amino acids CDHIMPQTVW
Common amino acids K
Mass 393789
Pl 12.18
Basic residues 11
Acidic residues 1
Hydrophobic residues 10
Net charge 10
Boman Index -8136
Hydrophobicity -98.57
Aliphatic Index 35
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 55.19
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19563807
Title N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins
Doi 10.1016/j.febslet.2009.06.044
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.