This work is licensed under a Creative Commons Attribution 4.0 International License.
Ltc-2a (4-26)
General Information
DRACP ID DRACP00222
Peptide Name Ltc-2a (4-26)
Sequence GKLIKKFGRKAISYAVKKARGKH
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL6 positive; Chronic myeloid leukemia | Leukemia | EC50>36 µM | Hoechst 33342 and PI assay | 3h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>36 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C119H206N38O26
Absent amino acids CDEMNPQTW
Common amino acids K
Mass 297778
Pl 11.97
Basic residues 10
Acidic residues 0
Hydrophobic residues 8
Net charge 10
Boman Index -4686
Hydrophobicity -76.52
Aliphatic Index 76.52
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 67.73
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19563807
Title N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins
Doi 10.1016/j.febslet.2009.06.044
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.