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Latarcin-5
General Information
DRACP ID DRACP00227
Peptide Name Latarcin-5
Sequence GFFGKMKEYFKKFGASFKRRFANLKKRL
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Lachesana tarabaevi
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | EC50=12 µM | Hoechst 33342 and PI assay | 3h | 1 |
Hemolytic Activity Rabbit erythrocytes: 20% Hemolysis=40 µM; Human erythrocytes: 50% Hemolysis=12 µM; 27% Hemolysis=256 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C164H253N45O34S
Absent amino acids CDHIPQTVW
Common amino acids K
Mass 391290
Pl 11.87
Basic residues 10
Acidic residues 1
Hydrophobic residues 10
Net charge 9
Boman Index -6409
Hydrophobicity -75.71
Aliphatic Index 35
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 55.19
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19563807
Title N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins
Doi 10.1016/j.febslet.2009.06.044
Year 2009
Literature 2
Pubmed ID 16735513
Title Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity
Year 2006
Literature 3
Pubmed ID 34576320
Title Membrane Interactions of Latarcins: Antimicrobial Peptides from Spider Venom
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.