This work is licensed under a Creative Commons Attribution 4.0 International License.
Callyaerin E
General Information
DRACP ID DRACP00239
Peptide Name Callyaerin E
Sequence LPFFPPVXPIIG
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Callyspongia aerizusa
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| L5178Y | Mouse leukemia | Leukemia | ED50=0.39µM | MTT assay | 72h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | ED50=3.4µM | MTT assay | 72h | 1 |
| PC-12 | Lung papillary adenocarcinoma | Carcinoma | ED50=3.8µM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond SMB: Leu1<--->X(8)
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=Daa
Chiral L
Physicochemical Information
Formula C63H91N11O11
Absent amino acids ACDEHKMNQRSTWY
Common amino acids P
Mass 148486
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 6
Net charge 0
Boman Index 2570
Hydrophobicity 131.67
Aliphatic Index 121.67
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20599387
Title Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.