Callyaerin F

General Information


DRACP ID  DRACP00240

Peptide Name   Callyaerin F

Sequence  VPVFPXPLF

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Callyspongia aerizusa

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
L5178Y Mouse leukemia Leukemia ED50>9µM MTT assay 72h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma ED50>9µM MTT assay 72h 1
PC-12 Lung papillary adenocarcinoma Carcinoma ED50>9µM MTT assay 72h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  SMB: Val1<--->X(6)

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X=Daa

Chiral  L



Physicochemical Information


Formula  C49H68N8O8

Absent amino acids  ACDEGHIKMNQRSTWY

Common amino acids  P

Mass  114999

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  5

Net charge  0

Boman Index  1896

Hydrophobicity  144.44

Aliphatic Index  107.78

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 20599387

Title  Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa

Doi 10.1016/j.bmc.2010.06.012

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.