This work is licensed under a Creative Commons Attribution 4.0 International License.
Peptide-20
General Information
DRACP ID DRACP00244
Peptide Name Peptide-20
Sequence CSSRTMHHC
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 90% viablity=100 µM | MTT assay | 48 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | 55% viablity=100 µM | MTT assay | 48 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 50% viablity=100 µM | MTT assay | 48 h | 1 |
| B16-F10 | Mouse melanoma | Carcinoma | 50% viablity=100 µM | MTT assay | 48 h | 1 |
| A2058 | Amelanotic melanoma | Carcinoma | 30% viablity=100 µM | MTT assay | 48 h | 1 |
| SK-MEL-25 | Melanoma | Carcinoma | 55-60% viablity=100 µM | MTT assay | 48 h | 1 |
| SK-MEL-28 | Cutaneous melanoma | Carcinoma | 35-40% viablity=100 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target cadherin constituent at the tumor cell surface
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C39H64N16O13S3
Absent amino acids ADEFGIKLNPQVWY
Common amino acids CHS
Mass 120409
Pl 8.25
Basic residues 3
Acidic residues 0
Hydrophobic residues 0
Net charge 3
Boman Index -2870
Hydrophobicity -70
Aliphatic Index 0
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 15.63
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20802991
Title A novel melanoma-targeting peptide screened by phage display exhibits antitumor activity
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.