This work is licensed under a Creative Commons Attribution 4.0 International License.
Dex-(KW)3
General Information
DRACP ID DRACP00245
Peptide Name Dex-(KW)3
Sequence KWKWKW
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PC-3 | Prostate carcinoma | Carcinoma | 60% viablity=10 µM | MTT assay | Not available | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | 35-40% viablity=10 µM | MTT assay | Not available | 1 |
Hemolytic Activity rabbit red blood cell: hemolysis=1.9±0.2%
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C51H68N12O7
Absent amino acids ACDEFGHILMNPQRSTVY
Common amino acids KW
Mass 105054
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 3
Net charge 3
Boman Index -966
Hydrophobicity -240
Aliphatic Index 0
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 16500
Absorbance 280nm 3300
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20964334
Title Synthesis, characterization, and thermodynamic study of a polyvalent lytic peptide-polymer conjugate as novel anticancer agent
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.