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Ranatuerin-2Lb
General Information
DRACP ID DRACP00257
Peptide Name Ranatuerin-2Lb
Sequence GILSSIKGVAKGVAKNVAAQLLDTLKCKITGC
Sequence Length 32
UniProt ID Not available
PubChem CID Not available
Origin Rana luteiventris; Rana pretiosa
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=15.32 µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=45.25 µM | MTT assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=37.23 µM | MTT assay | 24h | 1 |
| LoVo | Colon adenocarcinoma | Carcinoma | IC50=59.78 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>100 µM; Sheep erythrocytes: <10% Hemolysis=256 µM
Normal (non-cancerous) Cytotoxicity HEK293T: IC50=63.16 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys27<--->Cys32
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C140H251N39O41S2
Absent amino acids EFHMPRWY
Common amino acids K
Mass 375406
Pl 10.23
Basic residues 5
Acidic residues 1
Hydrophobic residues 14
Net charge 4
Boman Index -47
Hydrophobicity 59.06
Aliphatic Index 125
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 4.03
Polar residues 11
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34073203
Title Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides
Year 2021
Literature 2
Pubmed ID 21295070
Title Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis
Year 2011
Patent
Patent ID CN113855783A
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.