Oncocin [P13Hyp][R15Hyp][R19Orn]

General Information


DRACP ID  DRACP00260

Peptide Name   Oncocin [P13Hyp][R15Hyp][R19Orn]

Sequence  VDKPPYLPRPRPXRXIYNX

Sequence Length  19

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma Not active up to 2000µg/ml MTT assay 24h 1
HepG2 Hepatoblastoma Blastoma Not active up to 2000µg/ml MTT assay 24h 1

Hemolytic Activity  Human erythrocytes: Not active up to 600 µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X(13)= 4-Hydroxyproline; X(15)= 4-Hydroxyproline; X(19)=Orn

Chiral  L



Physicochemical Information


Formula  C92H139N27O19

Absent amino acids  ACEFGHMQSTW

Common amino acids  P

Mass  257850

Pl  10.64

Basic residues  4

Acidic residues  1

Hydrophobic residues  3

Net charge  3

Boman Index  -5207

Hydrophobicity  -118.42

Aliphatic Index  56.32

Half Life 
  /

Extinction Coefficient cystines  2980

Absorbance 280nm  165.56

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21387510

Title  Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex

Doi 10.1002/cbic.201000792

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.