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Oncocin [P13Hyp][R15Hyp][R19Orn]
General Information
DRACP ID DRACP00260
Peptide Name Oncocin [P13Hyp][R15Hyp][R19Orn]
Sequence VDKPPYLPRPRPXRXIYNX
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Not active up to 2000µg/ml | MTT assay | 24h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | Not active up to 2000µg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: Not active up to 600 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X(13)= 4-Hydroxyproline; X(15)= 4-Hydroxyproline; X(19)=Orn
Chiral L
Physicochemical Information
Formula C92H139N27O19
Absent amino acids ACEFGHMQSTW
Common amino acids P
Mass 257850
Pl 10.64
Basic residues 4
Acidic residues 1
Hydrophobic residues 3
Net charge 3
Boman Index -5207
Hydrophobicity -118.42
Aliphatic Index 56.32
Half Life
/
Extinction Coefficient cystines 2980
Absorbance 280nm 165.56
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21387510
Title Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.