Peptide Libraray

Oncocin [P13Hyp,R15Hyp,I16Tle,R19Orn]

General Information

DRACP ID DRACP00261

Peptide Name Oncocin [P13Hyp,R15Hyp,I16Tle,R19Orn]

Sequence VDKPPYLPRPRPXRXXYNX

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	Not active up to 2000µg/ml	MTT assay	24h	1
HepG2	Hepatoblastoma	Blastoma	Not active up to 2000µg/ml	MTT assay	24h	1

Hemolytic Activity Human erythrocytes: Not active up to 600 µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification X(13)= 4-Hydroxyproline; X(15)= 4-Hydroxyproline; X(16)=L-tert-leucine; X(19)=Orn

Chiral L

Physicochemical Information

Formula C86H126N26O17

Absent amino acids ACEFGHIMQSTW

Common amino acids P

Mass 255732

Pl 10.64

Basic residues 4

Acidic residues 1

Hydrophobic residues 2

Net charge 3

Boman Index -5699

Hydrophobicity -142.11

Aliphatic Index 35.79

Half Life
/

Extinction Coefficient cystines 2980

Absorbance 280nm 165.56

Polar residues 3

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 21387510

Title Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex

Doi 10.1002/cbic.201000792

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available